This years biggest breakthroughs in longevity research - 2022!!
What a year 2022 has been for longevity research. Take a trip down memory lane with me in this video as we chat from rapamycin, cellular reprogramming, CRISPR to cellular senescence.
SPONSOR: Come and join the discussion of research papers (in particular longevity) over at ResearchHub: https://www.researchhub.com/referral/...
Find me on Twitter - / eleanorsheekey
Support the channel
through PayPal - https://paypal.me/sheekeyscience?coun...
through Patreon - / thesheekeyscienceshow
TIMESTAMPS
Intro - 00:00
Lifespan regulation - 00:45
Rejuvenation & Regeneration - 04:00
Cellular senescence - 08:05
Technology, CRISPR, microscopy - 11:15
Lifestyle - diet & supplements - 13:50
Aging is... - 15:50
Sponsor - 18:25
References:
Jeon, O.H., Mehdipour, M., Gil, TH. et al. Systemic induction of senescence in young mice after single heterochronic blood exchange. Nat Metab 4, 995–1006 (2022). https://doi.org/10.1038/s42255-022-00...
An intercellular transfer of telomeres rescues T cells from senescence and promotes long-term immunological memory - https://www.nature.com/articles/s4155...
Acute multidrug delivery via a wearable bioreactor facilitates long-term limb regeneration - https://doi.org/10.1126/sciadv.abj2164
Moiseeva, V., Cisneros, A., Sica, V. et al. Senescence atlas reveals an aged-like inflamed niche that blunts muscle regeneration. Nature (2022). https://doi.org/10.1038/s41586-022-05...
Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans - https://doi.org/10.1016/j.ebiom.2022....
Selenium mediates exercise-induced adult neurogenesis https://doi.org/10.1016/j.cmet.2022.0...
A rare human centenarian variant of SIRT6 enhances genome stability - https://doi.org/10.15252/embj.2021110393
Multi-omic rejuvenation of human cells by maturation phase transient reprogramming https://doi.org/10.7554/eLife.71624
Papandreou, ME., Konstantinidis, G. & Tavernarakis, N. Nucleophagy delays aging and preserves germline immortality. Nat Aging (2022). https://doi.org/10.1038/s43587-022-00...
Kriebs, A. Body temperature not metabolic rate modulates lifespan. Nat Aging 2, 368 (2022). https://doi.org/10.1038/s43587-022-00...
Drag-and-drop genome insertion without DNA cleavage with CRISPR-directed integrases - https://doi.org/10.1101/2021.11.01.46...
Snyder, J.M., Casey, K.M., Galecki, A. et al. Canagliflozin retards age-related lesions in heart, kidney, liver, and adrenal gland in genetically heterogenous male mice. GeroScience (2022). https://doi.org/10.1007/s11357-022-00...
Transient rapamycin treatment during developmental stage extends lifespan in Mus musculus - https://doi.org/10.15252/embr.202255299
Browder, K.C., Reddy, P., Yamamoto, M. et al. In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice. Nat Aging 2, 243–253 (2022). https://doi.org/10.1038/s43587-022-00...
Please note that The Sheekey Science Show is distinct from Eleanor Sheekey's teaching and research roles at the University of Cambridge. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.
Icons in intro; "https://www.freepik.com/free-photos-v..."Background vector created by freepik - www.freepik.com