Webinar - Matched Annotation from the NCBI and EMBL-EBI (MANE)
This is the recording from the webinar held on 12 December 2018 on our new joint initiative: the Matched annotation from the NCBI and EMBL-EBI (MANE) project.
The aim of the project is to converge on transcript annotation to jointly define a high-confidence, genome-wide transcript set. All transcripts in the set will perfectly align to the GRCh38 reference assembly and represent 100% identity (5’UTR, CDS, 3’UTR) between the Ensembl (ENST) transcript and the corresponding RefSeq (NM) transcript. We anticipate this dataset will provide a common framework for clinical reporting, comparative genomics, and cross-study data comparisons.
Webinar Content
Webinar Part I – 0:0
Welcome – Joannella Morales (EMBL-EBI) - 0:2
Opening Remarks – Kim Pruitt (NCBI) – 0:27
Opening Remarks – Ewan Birney (EMBL-EBI) – 2:54
Aims and goals of the MANE project – Fiona Cunningham (EMBL-EBI) – 4:15
Basic Methodology – Terence Murphy (NCBI) – 22:08
Webinar Part II – 43:26
Deeper dive into the methodology – Shashikant Pujar (NCBI) – 43:28
Progress, challenges and limitations – Jane Loveland (EMBL-EBI) – 59:18
Sequence and update considerations – Terence Murphy (NCBI) – 1:11:37
MANE and LRG: How do they relate? – Joannella Morales (EMBL-EBI) – 1:26:53
Mane: Data access and display – Joannella Morales (EMBL-EBI) – 1:37:15
Summary – Joannella Morales (EMBL-EBI) – 1:40:45
Closing Remarks – Fiona Cunningham (EMBL-EBI) - 1:43:02