Longitudinal UBA1 tracking in VEXAS syndrome
In this interview, Carmelo Gurnari, MD, University of Rome Tor Vergata, Rome, Italy, and Cleveland Clinic, Cleveland, OH, provides insight into the development of a digital droplet PCR methodology for diagnosing and tracking UBA1 mutations in VEXAS syndrome, a condition characterized by somatic mutations in the UBA1 gene. Dr Gurnari explains that this validated approach provides a way to track the effect of different therapeutic approaches, including azacitidine and transplantation, on the molecular clonality of patients. This interview took place at the 51st Annual Meeting of the EBMT in Florence, Italy.
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