Example of playing Fallout 4 on ubuntu with wine + DXVK.
Wine version: ge-3.6-x86_64 and DXVK .53
The screen capture won't capture it fullscreen hence the window. Settings shown are maxed except resolution and godrays and are higher than what I usually run. There is an issue in windowed mode that the mouse won't stop at the border of the window.
The difference between fallout 4 in this instance and windows 10 on the same machine is about 5 fps.