Can Neurons Regenerate? * Neurogenesis
We have been told that when neurons are lost, they are lost forever. But is it true? Is it possible to recover neurons even as an adult?
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CHAPTERS
0:00 Intro: Chris Hemsworth and Alzheimer's
0:58 Why neurons can't reproduce
2:10 Neurogenesis at different ages
2:32 Neurogenesis in adults
4:24 How to promote neurogenesis?
6:28 Connections are worth more than the number of neurons
6:55 BDNF and how to promote it
TO KNOW MORE:
Moreno-Jiménez, EP, Flor-García, M., Terreros-Roncal, J., Rábano, A., Cafini, F., Pallas-Bazarra, N., ... & Llorens-Martín, M. (2019) . Adult hippocampal neurogenesis is abundant in neurologically healthy subjects and drops sharply in patients with Alzheimer's disease. Nature medicine, 25(4), 554-560 https://www.nature.com/articles/s4159...
Knoth, R., Singec, I., Ditter, M., Pantazis, G., Capetian, P., Meyer, RP, ... & Kempermann, G. (2010). Murine features of neurogenesis in the human hippocampus across the lifespan from 0 to 100 years. PloS one, 5(1), e8809.
https://journals.plos.org/plosone/art...
Leal-Galicia, P., Chávez-Hernández, ME, Mata, F., Mata-Luévanos, J., Rodríguez-Serrano, LM, Tapia-de-Jesús, A., & Buenrostro-Jáuregui, MH (2021). Adult neurogenesis: A story ranging from controversial new neurogenic areas and human adult neurogenesis to molecular regulation. International journal of molecular sciences, 22(21), 11489. https://www.mdpi.com/1422-0067/22/21/...
Kempermann, G., Kuhn, HG, & Gage, FH (1998). Experience-induced neurogenesis in the senescent dentate gyrus. Journal of Neuroscience, 18(9), 3206-3212. https://pubmed.ncbi.nlm.nih.gov/9547229/
Eriksson, PS, Perfilieva, E., Björk-Eriksson, T., Alborn, AM, Nordborg, C., Peterson, DA, & Gage, FH (1998). Neurogenesis in the adult human hippocampus. Nature medicine, 4(11), 1313-1317. https://www.nature.com/articles/nm119...
Gyorkos, A., Baker, MH, Miutz, LN, Lown, DA, Jones, MA, & Houghton-Rahrig, LD (2019). Carbohydrate-restricted diet and exercise increase brain-derived neurotrophic factor and cognitive function: a randomized crossover trial. Cureus, 11(9) https://www.cureus.com/articles/22650... crossover-trial#!/
CREDITS
Screenplay: Tonatiuh Moreno or Mariana González
Illustrations:
Erasmo Rodriguez / erasmono
Photography: Pako Rodríguez / fotoconk
Voice: Javier Lacroix / javierlacroix
Music: Miguel Solís, Mary Camarena and Jorge Verdín
Animation:
Alejandra Espinosa / alepan_ca
Sofia Espinosa / miss_sofyjones
Editing: Erick Blackmer https://www.imdb.com/name/nm8710137/