This is a Necromancer set added in patch 2.6.0 featuring blood skills, i.e. life-spending abilities, as well as healing skills.
(2) Set:
Blood Rush gains the effect of every rune.
(4) Set:
While at full Life, your healing from skills is added to your maximum Life for 45 seconds, up to 100% more.
(6) Set:
Your Life-spending abilities deal 3300% increased damage but cost twice as much Life. Your healing from skills is increased by 100%.
2 pieces bonus improves Blood Rush, allowing it to increase armor, heal and create corpses at the same time, with 2 charges and does not cost health.
6 pieces bonus greatly buff the damage of your life-spending abilities (i.e. any skill runes that cost health to cast). However, costing twice as much Life do cause problem. Typical life-spending spenders cost 10% health. With the set, it is 20% health, so you can only cast 4 times successively which leaves you at 20% health! Therefore, you need several healing skills and use life-spending and healing skills intermittently. At least the healing from skills is also double.
4 pieces bonus basically double your maximum health with time. However, it is kind of counterproductive with the 6 set bonus because with higher maximum health, life-spending skills 20% cost means you are losing double amount of life for each cast. In my humble opinion it would make more sense by simply making it gives a 50% damage reduction likes most other sets 4 pieces bonus.