How to know if two genes are similar? | Semantic Similarity Explained
Well, how do we do know that two genes are close together by looking at their GO annotation? Wang et al 2007 attempt the answer the question by using graph theory.
Slide
https://docs.google.com/presentation/...
R Code
https://drive.google.com/file/d/1vaMO...
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Chapters:
0:00 Intro
0:20 Semantic Similarity definition
0:58 What is Gene Ontology
1:47 How GO works
3:37 Relationships between terms
4:18 The equations !!!!
4:30 Graph Theory
5:23 An example of GOSemSim calculation
8:07 What if there is more than 1 GO term?
10:46 Pretty animation
11:40 The R code and expected output
14:00 Notes