This example demonstrates how to set up, use, and measure the performance of a USB HID communication in a real-time open-loop host-to-target hardware in the loop (HIL) simulation settings. You will learn how to set up, use, and analyze system performance from both Simulink and Matlab command-line (m-file) environments. You will be shown how to create graphical user interface (GUI) toggle and push buttons that allow users to interactively control the target in real-time directly from Simulink.