To unlock the Two Bugs, One Stone achievement in Resident Evil 4 Remake you must destroy 2 parasites inside a Regenerador with a single bullet.
In Chapter 13 of the game, you will come across Regenerators for the first time. The first two Regenerators you encounter are tough to beat since you cannot see their weak spots. The best way to deal with them is to shoot off their leg and run away. Later, when you obtain the Level 2 security card and need to upgrade it to Level 3, you will require a wrench for the card terminal. In the same room, you can find a Thermal Vision Scope (Biometric Scope) that you can attach to a sniper rifle or a machine gun. Attach it to a sniper rifle and aim to see the weak spots. The Regenerator in the second tank on the left is the easiest to defeat. Since they do not move from the tanks until you shoot them, you can line up a shot with the sniper rifle to destroy two parasites at once. Any sniper rifle is strong enough to destroy two weak spots with one bullet; you do not need any damage upgrades.
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