Retaining the play's poetic style, the film's lead cast consists of nine African-American women, seven of whom are based on the play's seven characters only known by color ("Lady in Red", "Lady in black"Lady in Yellow", etc.). Like its source material, each character deals with a different personal conflict, such as love, abandonment, rape, infidelity, and abortion. The characters are represented by a color: Jo/Red (Janet Jackson), Juanita/Green (Loretta Devine), Yasmine/Yellow (Anika Noni Rose), Tangie/Orange (Thandie Newton), Alice/White (Whoopi Goldberg), Gilda/Gray (Phylicia Rashad), Crystal/Brown (Kimberly Elise), Nyla/Purple (Tessa Thompson), and Kelly/Blue (Kerry Washington). Each of their stories are different, but the characters interact within each other's lives.
The show opens with Tangie throwing her latest lover out of her house. Right after that, as Juanita arrives to piss Frank off with a houseplant, Kelly, who works for child welfare, attempts to visit Crystal on behalf of the children, but she does not get very far. As she flees her drug-addicted husband, Beau Willie, she gets some good advice from Gilda. Meanwhile, Alice shows up to beseech Tangie for money, but gets rebuffed instead. Alice goes out to raise money, and encounters Yasmine, who gives her a little money. Yasmine, a dance teacher, is boasting of how dancing gives her underprivileged girls opportunities, a way out of the ghetto, and in to college. Nyla tells her friends in the class about her graduation night with a pack of cousins, then has to throw up. Kelly's husband comes over and arrests two men, one of whom is Jo's husband. Juanita is waiting in Jo's office, with Jo's terrified assistant, Katina, running scared and making tea, and Crystal running late for work. Jo rejects the work of her photographers, demanding work of the highest caliber.