Aspirin for 1° and 2° Prevention of ASCVD – Prof. Mora (Boston, MA), Prof. Cleland (Glasgow, UK)
Dr Samia Mora (Boston, MA, USA) and Dr. John Cleland (Glasgow, Scotland, UK) discuss the indication for (or against) aspirin treatment in primary and secondary prevention of atherosclerotic cardiovascular disease.
Dr. John Cleland is Professor of Cardiology at the University of Glasgow, UK. He founded the European Journal of Heart Failure, and he is Past-Chair of the ESC Working Group on heart failure and British Society for Heart Failure.
Dr Samia Mora is Professor of Medicine, Harvard Medical School and Associate Physician at Brigham and Women’s Hospital, and Director of the Center for Lipid Metabolomics.
Dr. Mora co-developed the free Aspirin-Guide mobile app for aspirin in primary prevention of cardiovascular disease (available on the web on www.aspiringuide.com), and she is Co-Principal Investigator of the Women’s Health Study.
The interview was recorded on January 24th, 2025. Moderators: Prof. Dr. Dr. Stephan Schirmer (Kaiserslautern, Germany) and Prof. Dr. Gunnar Heine (Frankfurt, Germany).
Articles discussed:
Aspirin for Secondary Prevention of Atherosclerosis-Evidence or Dogma?
Cleland JGF
JAMA Cardiol 2024
doi: 10.1001/jamacardio.2024.4335
Aspirin to target arterial events in chronic kidney disease (ATTACK): study protocol for a multicentre, prospective, randomised, open-label, blinded endpoint, parallel group trial of low-dose aspirin vs. standard care for the primary prevention of cardiovascular disease in people with chronic kidney disease.
Gallagher H et al.
Trials 2022
doi: 10.1186/s13063-022-06132-z
Aspirin versus clopidogrel for chronic maintenance monotherapy after percutaneous coronary intervention (HOST-EXAM): an investigator-initiated, prospective, randomised, open-label, multicentre trial.
Koo BK et al.; HOST-EXAM investigators.
Lancet 2021
doi: 10.1016/S0140-6736(21)01063-1
Low-Dose Aspirin in the Primary Prevention of Cardiovascular Disease: Shared Decision Making in Clinical Practice.
Mora S, Ames JM, Manson JE
JAMA 2016
doi: 10.1001/jama.2016.8362
Whom to Treat for Primary Prevention of Atherosclerotic Cardiovascular Disease: The Aspirin Dilemma.
Mora S, Shufelt CL, Manson JE.
JAMA Intern Med 2022
doi: 10.1001/jamainternmed.2022.1365
Aspirin for the Primary Prevention of Atherosclerotic Cardiovascular Disease in Women.
Shufelt CL, Mora S, Manson JE.
JAMA 2022
doi: 10.1001/jama.2022.11951
Aspirin for Primary Prevention of Atherosclerotic Cardiovascular Disease: Advances in Diagnosis and Treatment.
Mora S, Manson JE.
JAMA Intern Med 2016
doi: 10.1001/jamainternmed.2016.2648
Pantoprazole to Prevent Gastroduodenal Events in Patients Receiving Rivaroxaban and/or Aspirin in a Randomized, Double-Blind, Placebo-Controlled Trial.
Moayyedi P et al.; COMPASS Investigators.
Gastroenterology 2019
doi: 10.1053/j.gastro.2019.04.041
Rivaroxaban with or without Aspirin in Stable Cardiovascular Disease.
Eikelboom JW, et al.; COMPASS Investigators.
N Engl J Med 2017
doi: 10.1056/NEJMoa1709118
Long-term follow-up of the West of Scotland Coronary Prevention Study.
Ford I et al.; West of Scotland Coronary Prevention Study Group.
N Engl J Med 2007
doi: 10.1056/NEJMoa065994
Beta-Blockers after Myocardial Infarction and Preserved Ejection Fraction.
Yndigegn T et al.; REDUCE-AMI Investigators
N Engl J Med 2024
doi: 10.1056/NEJMoa2401479
Polypill with or without Aspirin in Persons without Cardiovascular Disease.
Yusuf S et al.; International Polycap Study 3 Investigators.
N Engl J Med 2021
doi: 10.1056/NEJMoa2028220
Polypill Strategy in Secondary Cardiovascular Prevention.
Castellano JM et al.; SECURE Investigators.
N Engl J Med 2022
doi: 10.1056/NEJMoa2208275
Effects of Aspirin for Primary Prevention in Persons with Diabetes Mellitus.
ASCEND Study Collaborative Group; Bowman L et al.
N Engl J Med 2018
doi: 10.1056/NEJMoa1804988