Precision-T trial: Orca-T vs tacrolimus-methotrexate for GvHD prevention in hematologic malignancies
Rawan Faramand, MD, Moffitt Cancer Center, Tampa, FL, shares insights into the Phase III Precision-T trial (NCT05316701), which compared standard graft-versus-host disease (GvHD) prevention with tacrolimus-methotrexate to Orca-T, an investigational allogeneic T-cell product. Dr Faramand explains that Orca-T utilizes highly purified regulatory and conventional T-cells in a defined one-to-one ratio, aiming to improve immune reconstitution, reduce rates of severe chronic GVHD, and maintain graft-versus-leukemia effect. This interview took place at the 13th Annual Meeting of the Society of Hematologic Oncology (SOHO 2025) in Houston, TX.
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