Fake Acid? It's probably NBOMe
𝟮𝟱𝘅-𝗡𝗕𝗢𝗠𝗲 – Unraveling the Mysterious LSD Alternative 🌠
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• 𝟮𝟱𝘅-𝗡𝗕𝗢𝗠𝗲 – Unraveling the Mysterious LSD ...
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► 𝗜𝗡𝗦𝗧𝗔𝗚𝗥𝗔𝗠: @lowkey_fish ◄
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This video articulates the gist of the following: Recently, a new class of psychedelic compounds named NBOMe (or 25X-NBOMe) has appeared on the illegal substance market. NBOMes are analogs of the 2C family of phenethylamine substances, originally synthesized by Alexander Shulgin, that contain a N-(2-methoxy)benzyl substituent. The most frequently reported substances from this group are 25I-NBOMe, 25B-NBOMe, and 25C-NBOMe. NBOMe compounds are ultrapotent and highly efficacious agonists of serotonin 5-HT2A and 5-HT2C receptors (Ki values in low nanomolar range) with more than 1000-fold selectivity for 5-HT2A compared with 5-HT1A. They display higher affinity for 5-HT2A receptors than their 2C counterparts and have markedly lower affinity, potency, and efficacy at the 5-HT2B receptor compared to 5-HT2A or 5-HT2C. The substances are sold as blotter papers, or in powder, liquid, or tablet form, and they are administered sublingually/buccally, intravenously, via nasal insufflations, or by smoking. Since their introduction in the early 2010s, numerous reports have been published on clinical intoxications and fatalities resulting from the consumption of NBOMe compounds. Commonly observed adverse effects include visual and auditory hallucinations, confusion, anxiety, panic and fear, agitation, uncontrollable violent behavior, seizures, excited delirium, and sympathomimetic signs such mydriasis, tachycardia, hypertension, hyperthermia, and diaphoresis. Rhabdomyolysis, disseminated intravascular coagulation, hypoglycemia, metabolic acidosis, and multiorgan failure were also reported. This survey provides an updated overview of the pharmacological properties, pattern of use, metabolism, and desired effects associated with NBOMe use. Special emphasis is given to cases of non-fatal and lethal intoxication involving these compounds. As the analysis of NBOMes in biological materials can be challenging even for laboratories applying modern sensitive techniques, this paper also presents the analytical methods most commonly used for detection and identification of NBOMes and their metabolites. N-Bomb, Bom-25, 2C-I-NBOMe, 25-I-NBOMe, 25I, Pandora, Solaris, Divination, Wizard, and Smiley Paper are slang names. There are concerns that NBOMes may sometimes be incorrectly sold as other substances, such as LSD.
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#NBOMe #Psychedelic #Tabs #NBOMe #FakeAcid #PsychedelicDrugs #NBOMeVsLSD #DrugAwareness #PsychedelicScience #NBOMeEffects #LSDAlternatives #DrugSafety #NBOMeRisks
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