Targeting Treatment-Resistant Mutations using "Off Target" Targeted Therapies

Опубликовано: 11 Март 2026
на канале: The Cancer Guy
1,707
11

In this video, Precision Oncology specialist, Alex Rolland, discusses how to target treatment-resistant mutations using “off target” targeted drugs. Many patients on targeted therapies can develop treatment resistant mutations or may have treatment-resistant mutations at the start of treatment...

Alex explains how we can use targeted drugs that would normally only be used to target other genes by looking at the mechanisms unique to each mutation and drug and matching them – in other words, by matching the drug mechanism to the mutation mechanism.

He is joined by Precision Oncology Advocate and CTOAM cofounder, Michelle Morand. They share the key takeaways that all cancer patients, their loved ones, and their doctors need to know about using “off target” targeted therapies to target treatment-resistant mutations.

00:00 Introduction
00:16 Alex’s Presentation: The Next Level in Precision Oncology: How to Target Treatment-Resistance Mutations using “Off target” Targeted Therapies
2:00 What treatment resistance genes are
234 What a genetic mutation is
5:15 How many mutations each gene can actually have
7:15 Why standard genetic testing just doesn’t cut it
8:01 The foundation of Precision Oncology - identifying targetable driving mutations
10:55 What happens if a patient has a mutation with no therapeutic strategies
14:02 New insights on this topic from computational simulations
15:41 Exploring a case study with the EGFR mutation
17:25 An inspiring patient story using this exact strategy – that worked!
22:14 Next steps you can take to determine the best treatment strategy for you and how to access it asap

Watch our interview with Gail, who went from Stage 4 with no more options to complete response in under three months – using this same approach!
   • From Stage 4 Cancer to Complete Response -...  

If you’d like to identify the most effective treatment for your cancer, and how to access it as soon as possible (and through your current treatment team, for as little cost as possible), reach out to us and book a free 30-min consult using the link below 👇

Book a Free Session With Alex And His Precision Oncology Team: https://www.ctoam.com/free-strategy-s...

Download CTOAM’S Free Ebook Here: https://www.ctoam.com/ebook/

-

CTOAM is a worldwide, Canadian-based personalized cancer care and precision oncology service specializing in getting our client's rapid access to the best possible cancer treatment available for their form of cancer, while assisting their physicians in having the most current data from which to make confident treatment decisions on your behalf.

We facilitate access to peer-reviewed, science-based precision diagnostics such as PET/CT scans, liquid biopsy (blood-based genetic tests) and detailed genetic panels. We use these leading diagnostic tools, combined with a thorough and personalized research review, as our team explores the most advanced scientific data available today to find the best options for you.

Other ways to stay in touch with CTOAM:

Facebook:   / cancertreatmentoptionsandmanagement  
LinkedIn:   / ctoam  
Twitter:   / ctoam  
Blog: https://research.ctoam.com/


LinkedIn (Liquid Biopsy Labs):   / 13063544  
LBL Twitter:   / liquidbiopsynow  


Disclaimer:

Please understand that these videos are meant for educational purposes only. These videos are not intended to diagnose or be used as treatment advice. Viewers are encouraged to speak with their doctor or healthcare professionals for medical advice and before making any changes to their healthcare based on this information. All statements made in this video regarding medical treatments and health conditions are sourced and have been approved by the U.S. Food and Drug Administration (FDA). Watching this video is not a substitute for professional medical advice or a diagnosis.