The properties of the blood oxygen level-dependent (BOLD) signal, as measured with fMRI, impose important constraints on the design of fMRI experiments, and on the analysis and interpretation of the resultant data.
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Relevant paper:
Riggall, A. C., & Postle, B. R. (2012). The relationship between working memory storage and elevated activity as measured with functional magnetic resonance imaging. Journal of Neuroscience, 32(38), 12990-12998.