Megaloblastic anemia is typically caused by a deficiency in either vitamin B12 or folate, leading to impaired DNA synthesis and the production of abnormally large red blood cells (megaloblasts). Diagnosing this condition involves a series of laboratory tests, some basic tests include:
Complete blood count:
Peripheral blood film examination:
Serum Vitamin B12 Levels: Low levels suggest a deficiency. Normal or low-normal levels may necessitate further testing (e.g., methylmalonic acid).
Serum folate levels:
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