Answers from the Experts: Q&A - May 2024
Do you have questions about cutaneous lymphoma and/or treatments? Our clinical Q&A's are a great way to learn more and empower yourself with knowledge from experts in their field.
Clinical Panel
Mary Jo Lechowicz, MD, Winship Cancer Institute - Emory University
Zachary Wolner, MD Winship Cancer Institute - Emory University
Timestamps
01:46 "Is there any other option besides doing Moga every 14 days for the rest of my life?
Will this flakey rash ever go away ?"
03:12 I am stage 2B. Smear showed leukemic picture with sezary cells. Flow Cytometry came back normal. Being considered for PUVA / methotrexate / spot radiation. Benefits & side effects of each and how to choose?
06:19 Can Sezary syndrome cause memory loss as it progresses?
07:44 How much does stress impact MF?
08:48 Is a Buffy coat smear (Sezary preparation) better than flow cytometry in picking up tumor cells in the blood?
10:22 Do you have any experience with Sunburn/UV issues on the most affected skin areas.
11:40 How often does someone with stage 1A progress to more advanced disease that may become life threatening?
12:47 I was diagnosed with Primary Cutaneous Anaplastic Large Cell Lymphoma in 2018 (one lesion) and again in 2020, same diagnosis, new (lesion). What is the likelihood of a recurrence of the disease now that it is 3+ years since the last event?
13:55 I was diagnosed with MF Stage 1B in April 2022. It is well controlled with NBUVB/Acitretin. I continue to struggle with an itchy scalp.
16:04 With CRISPR in the news regarding actually editing out a disease from cells, is that a viable area of research for people with t-cell lymphomas?
17:04 I have been treated with UVB therapy with resolution of rash (Stage I A). Is it important to treat recurrent or new skin lesions that remain minimal?
18:16 What new treatments can put CTCL in remission?
21:17 How many positive biopsy results are required to confirm a diagnosis of MF?
23:00 How common is it for people with PCFCL to have systemic involvement? What percentage of patients have eventual other types of lymphoma?
25:03 Is targeted radiation the best approach to a bump that was cut open, cleaned and stitched, and later learned to be PCMZL?
29:09 Have you experienced lymphoproliferative disorder in the mouth and how to best diagnose whether LyP or PCALCL?
32:31 For Mycosis Fungoides, what is a good way to resolve itching especially at night?
33:48 Can you talk about lifespan? My husband has Sezary syndrome Stage IV2B, Everything online says 2-4 years but his doctor says decades.
36:55 How frequently does the cost of treatment or therapy become a major consideration in choice of medications and how do you share that with your patients?
40:22 Most recent literature describes "lumps & bumps" where previously I just noted "tumors" as part of symptoms. What changed?
41:39 Should MOGA and ECP (Photopheresis) be used simultaneously?
42:55 With patients being treated with Mogamulizumab, how long have you seen consistent efficacy?
44:32 Does treatment halt progression or just help symptoms?
46:16 I have been doing NBUVB for 3 years and though my MF has improved greatly, still no sign of going into remission. Is this uncommon?
47:34 How effective is surgery to remove a lesion of PCALCL, how deep should they go? Does it remove muscle, or lymph nodes?