When dealing with wrist pain a while back, automating shortcuts with AutoHotkey helped me avoid aggravating the situation further. For example, instead of contorting my hands for each copy-paste for hundreds of times every day, I managed to remap Ctrl+C into a single keystroke on the top side of the keyboard, which would allow my hand to remain straight and comfortable. This is but one of the many examples I go through in this video. Here you'll find all you need to know to get started with AutoHotkey and automating/simplifying keyboard shortcuts.