Going from Sculptris to Unity using Ultimate Unwrap 3D Pro for Poly Reduce, Blender for Rigging, and Unity for the engine. This method will make your model Mecanim ready for animations.
Unity Mecanim Bone Reference Image:
https://i.postimg.cc/SQpPBh6g/Mecanim...
Blender: http://www.blender.org/
Sculptris: http://pixologic.com/sculptris/
Ultimate Unwrap 3D: http://uu3d.com/