TUTORIAL: Data Loading and Curation
There are several preparatory steps required before the tranSMART Framework for Curation and Data Loading can be accessed from a Mac. This tutorial shows Mac users which pieces of supportive software they will need to install, how to use them, and how to navigate to the Framework for Curation and Data Loading through the server. Additionally, the tutorial shows how to set preferences once the Framework is launched.
About the Sorlie GSE4382 Dataset:
According to the Sorlie GSE4328 abstract, the study "refined the previously defined subtypes of breast tumors that could be distinguished by their distinct patterns of gene expression. A total of 115 malignant breast tumors were analyzed by hierarchical clustering based on patterns of expression of 534 'intrinsic' genes...The genes used for classification were selected based on their similar expression levels between pairs of consecutive samples taken from the same tumor separated by 15 weeks of neoadjuvant treatment...[The] results strongly support the idea that many of these breast tumor subtypes represent biologically distinct disease entities."
Sorlie T, Tibshirani R, Parker J, Hastie T et al. Repeated observation of breast tumor subtypes in independent gene expression data sets. Proc Natl Acad Sci U S A 2003 Jul 8;100(14):8418-23. PMID: 12829800