The Sinaloa Cartel is the most powerful criminal organization in Mexico and one of the most influential in the world. Its historical leader, Joaquín "El Chapo" Guzmán, was sentenced to life imprisonment in the United States, but the cartel continues to operate under the command of his sons and other associates. The cartel has infiltrated and corrupted public officials, police officers, military personnel, and judges to facilitate its illicit operations. It has also generated a climate of violence and insecurity in several regions of the country, where it disputes control of territories and routes with other rival groups. The Sinaloa Cartel represents a challenge for the Mexican state and for international cooperation in security and justice. Combating it requires a comprehensive strategy that is not only based on the capture of its leaders but also on dismantling its financial, logistical, and social networks. Likewise, a social policy is needed that provides development opportunities for the young people recruited by the cartel as hitmen or drug mules. The Sinaloa Cartel is a complex phenomenon that reflects the deep inequalities and contradictions in Mexico.