In Terraria (v1.4.3.6), when playing with the Calamity Mod, after entering Hard Mode from defeating the Wall of Flesh and defeating a Mechanical Boss (for example, the Destroyer), the Orichalcum armor set can be used along with the Daedalus Stormbow to defeat Cryogen on the Surface in a Snow biome. Staggered platforms provide room to dodge and block the many particles. The Celestial Claymore's particles tear up Cryogen, who generally likes to stay close. Dashing (with Shield of Cthulhu or Evasion Scarf) are helpful for avoiding attacks and obtaining invincibility frames.
Armor & Accessories (Optimized for Damage then Dashing)
Orichalcum Mask (melee)
Orichalcum Breastplate
Orichalcum Leggings
Menacing Warrior Emblem
Menacing Fin Wings (from Angler's Quest)
Menacing Shield of Cthulhu
Menacing Shark Tooth Necklace
Menacing Brain of Chthulhu
Menacing Ankh Shield
Menacing Terraspark Boots
Weapon & Potions:
Legendary Celestial Claymore
Seafood
Regeneration Potion
Swiftness Potion
Ironskin Potion
Thorns Potion
Heart Reach Potion
Titan Potion
Lifeforce Potion
Endurance Potion
Rage Potion
Inferno Potion
Wrath Potion
Warmth Potion
Flask of Ichor
For more details, please see:
https://calamitymod.wiki.gg/wiki/Cryogen