JIBCON - When Harry Met Sally Reenactment - Jensen/Misha
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During the panel, a fan requested that Jensen and Misha act out something from a script. They were hesitant but when Jensen read the script he laughed and said "We can do this" because actors can "make choices".
This is the famous orgasm scene in When Harry Met Sally. The line read by the fan is "I'll have what she's having".