Botulinum Neurotoxin Inhibitors Identification by Imaging Assay | Protocol Preview
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A High Content Imaging Assay for Identification of Botulinum Neurotoxin Inhibitors - a 2 minute Preview of the Experimental Protocol
Krishna P. Kota, Veronica Soloveva, Laura M. Wanner, Glenn Gomba, Erkan Kiris, Rekha G. Panchal, Christopher D. Kane, Sina Bavari
Perkin Elmer Inc.,; Henry M. Jackson Foundation,; The Geneva Foundation,; ORISE,; Frederick National Laboratory for Cancer Research,; US Army Medical Research Institute of Infectious Diseases, Division of Molecular and Translational Sciences; US Army Medical Research and Materiel Command (USAMRMC), DoD Biotechnology High Performance Computing Software Applications Institute (BHSAI), Telemedicine and Advanced Technology Research Center (TATRC);
Botulinum neurotoxin is one of the most potent toxins among Category-A biothreat agents, yet a post-exposure therapeutic is not available. The high content imaging approach is a powerful methodology for identifying novel inhibitors as it enables multiparameter screening using biologically relevant motor neurons, the primary target of this toxin.
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