INTRACELLULAR ACCUMULATIONS: LIPIDS- Fatty Change
A series of video tutorials discussing the topics for undergraduates in Pathology
In this tutorial , i have discussed Intracellular accumulations- accumulation of lipids- Fatty change
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• Intracellular accumulations
• Overview
• Intracellular accumulation of lipids
• Accumulation of Neutral fat (a triester of fatty acids and glycerol ) :Fatty change
• Accumulation of cholesterol and cholesterol esters.
• Manifestation of metabolic derangement
• Accumulation may be transient & reversible or permanent. Effects: range from harmless to toxic
FATTY CHANGE
• Steatosis
• Fatty metamorphosis
• Intracellular accumulation of neutral fat(triglycerides) within the parenchymal cells.
• Common in liver
• Can occur in heart, skeletal muscle and kidneys.
CAUSES
• ALCHOL ABUSE
• - Diabetes mellitus
• - Obesity
• - Protien Malnutrion (starvation)
• -Drugs/toxins
• -Anoxia/Hypoxia
• -Pregnancy
Other Lipid Accumulations
• Cholesterol and cholesterol esters
• In atherosclerosis, cholesterol accumulates in smooth muscle cells and macrophages in the intima of arteries
• In hereditary hyperlipemia, cholesterol accumulates in macrophages, usually under the skin, forming tumor-like structures known as xanthomas
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Please watch: "WARBURG EFFECT: Hallmark of CANCER. What, Why & How?"
• NEOPLASIA 6: WARBURG EFFECT: Hallmark...
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