Visual Basic How To: Changing from 32Bit to 64Bit
A quick run through on changing your program from x86 (32 bit) to x64 (64 bit).
Make sure this is on: Tools ⇒ Options ⇒ Projects and Solutions ⇒ General ⇒ "Show advanced build configurations"
VB2010 link: http://go.microsoft.com/?linkid=9709929