How to fix most Smite errors
Usually it's because you by accident shut down a process called HiPatchService, or it simply didn't boot with your computer.
Just do as I do in the video and you should be good to go.
If you don't feel like you are up to the task of doing it manually, you can run this batch file as administrator: http://adf.ly/eJ3Jo
Step-by-step guide:
Open CMD as Administrator
type in the following "net start HiPatchService"
Click Enter
You should be able to open and play Smite now.
If not, do not hesitate to leave a comment with your problem. Or try the official Uninstall Tool supplied by Hi-Rez Support: http://adf.ly/juzzk
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Enjoy and have a good day :)