Daniel Choquet: "Des récepteurs qui bougent énormément ! " Bordeaux Neurocampus
"Glutamate-Induced AMPA Receptor Desensitization Increases Mobility and Modulates Short-Term Plasticity through Unbinding from Stargazin"
Audrey Constals, Andrew C. Penn, Benjamin Compans, Estelle Toulme, Amandine Phillipat, Sebastien Marais, Natacha Retailleau, Anne-Sophie Hafner, Francoise Coussen, Eric Hosy, and Daniel Choquet,
University of Bordeaux, Interdisciplinary Institute for Neuroscience, France , UMR 5297, Bordeaux Imaging Center, INSERM,
Neuron 85, 1–17, February 18, 2015 a2015 Elsevier Inc.
In conclusion, we have shown that:
Glutamate increases AMPAR diffusion in a conformation-dependent manner
Desensitized AMPAR diffuse faster than closed/resting or open ones
Desensitized AMPAR dissociate from stargazin
Glutamate induced AMPAR mobility speeds recovery from synaptic short-term depression
http://www.neuroscience.univ-bordeaux...