The story follows where the original left off. It is set on Spaceship ESS Meridian after the death of Professor Wagner, the antagonist in the first game. The player has to fight soldiers sent to the facility. The other protagonists include Danette, who was also a lab experiment and apparently was born in the ship. Another is Minikin, who is the best (and probably only) mechanic on the ship. He suffered brain damage while in cryostasis, being considered by the main character to be "retarded". He's the character who you would go to for weapons, weapon upgrades, etc. Doctor Bielik is a scientist whom you save and was working on your character by inserting implants all over the character's body before the infection. He is the person whom you go to for implant upgrades and gear.