Here's a basic map of a "death run", a type of mission you would be doing to do smuggle quests between city blocks through abandoned city areas.
I show the new climbing mechanic, which allows you to use elevation to escape enemies.
You can see three type of enemies here:
Ghouls, typical late-stage infected/half-rotten carcasses.
Reavers, ex-military with rejected implants and mostly infected too.
Security drones, automated defence systems of the city.