Vengeful Guardian: Moonrider - No Damage Trophy Guide
Before doing doing this I strongly suggest beating Vengeful Guardian: Moonrider, and collecting at least collecting the Acrobat (Lost Ruins 1/2), and Soul Eater (Asura's Fleet 2/2) chips. They don't do much, but it's enough to vastly decrease your chances of failure.
Beyond that, it's really all timing. Knowing every enemy spawn, along with knowing when to attack the bosses is going to be the difference between a win, and loss. Like, shooting the hand at the end too early will not destroy it, and almost certainly result in you taking damage, as will some random enemies. That said, I like to think this guide makes it so practically anyone can get this trophy without breaking a sweat.