A disease is a particular abnormal condition that affects part or all of an organism not caused by external force[1][2] (see 'injury') and that consists of a disorder of a structure or function, usually serving as an evolutionary disadvantage. The study of disease is called pathology, which includes the study of cause. Disease is often construed as a medical condition associated with specific symptoms and signs.[3] It may be caused by external factors such as pathogens or by internal dysfunctions, particularly of the immune system, such as an immunodeficiency, or by a hypersensitivity, including allergies and autoimmunity.
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