Hammett Equation
Hammett equation was developed and published by Louis Plack Hammett in 1937. describes a linear free-energy relationship relating reaction rates and equilibrium constants for many reactions involving benzoic acid derivatives with meta- and para-substituents to each other with just two parameters: a substituent constant and a reaction constant. It helps in understanding reaction mechanism, nature of substituents, quantitative structure activity relationship in drug design etc. Following points have been covered in this video: 1. Basic understanding of Hammett equation, 2. Substituents constant (sigma x) and its physical significance and 3. reaction constant (rho) and its physical significance, where we will learn correlation between rho value and reaction mechanism for different reactions.
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