Pattern recognition receptor | Immune system | PRRs | PAMPs | DAMPs | Basic Science Series
0:00 Introduction
0:30 PRRs
0:51 About PRRs
1:20 PAMPs
1:36 DAMPS
1:56 PRRs Types
2:05 Membrane bound
2:11 Cytoplasmic sensor
2:18 Inflammasomes
2:27 Innate Immunity
2:52 About PAMPs
3:10 Roles in Medicine
3:57 Summary
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Pattern recognition receptors (PRRs) play a crucial role in the proper function of the innate immune system. PRRs are germline-encoded host sensors, which detect molecules typical for the pathogens. They are proteins expressed, mainly, by cells of the innate immune system, such as dendritic cells, macrophages, monocytes, neutrophils, and epithelial cells.
PRRs play a crucial role in the proper function of the innate immune system. PRRs are germline-encoded host sensors, which detect molecules typical for the pathogens.
two classes of molecules: pathogen-associated molecular patterns (PAMPs), which are associated with microbial pathogens, and damage-associated molecular patterns (DAMPs), which are associated with components of host's cells that are released during cell damage or death. They are also called primitive pattern recognition receptors because they evolved before other parts of the immune system, particularly before adaptive immunity. PRRs also mediate the initiation of antigen-specific adaptive immune response and release of inflammatory cytokines.
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