This boss's elemental type switches from week to week.
Team is generally
Yui, (Dark Lord/Megumin), (Aina/Airi/Joan), Darkness
If Boss is Dark: Use Dark Lord and Airi. Dark Lord has been buffed to deal extra damage to dark type enemies and Airi provides offensive and defensive team buffs.
If Boss is Light or Fire: You can use Megumin or another Mage if you don't have Megumin. Instead of Airi, use Aina if the boss is Fire or Joan if the boss is Light since those 2 characters reduce the team's damage taken by fire and light enemies respectively.
If Boss is Leaf or Water: You can use Megumin or another Mage if you don't have Megumin. Use Airi for the offensive and defensive buffs to the team.
Position (1,2,3,4,5) -Boss where 5 is Cain by default
This boss normally won't be able to reach the very back person (position 1). This is a great spot to place your healer. If you happen to have a warrior such as Airi/Darkness/Vivian that can act as a tank, I know Vivian and Darkness will definitely step in front of Cain. This pushes the rest of the team back and as a result, slots 1 and 2 will actually be safe from harm. In other words, you can protect the back 2 people if you have a warrior step in front of Cain to widen the gap between the boss and your back line. This is why my Dark Lord and Yui are both protected. If you go into battle and find that the boss still hits 2,3,4, and 5, then exit the raid and re-enter until you see that slots 1 and 2 do not get hit.