How Neurons Communicate: Transient Pores in Hemifusion Diaphragms
In order to move material across two membranes, it is convenient to merge the membranes, forming a 'hemifusion diaphragm' (HD) then create a pore in the HD to allow material to pass. As part of a quantitative synaptology project, we investigated mechanisms by which cells can control the stability and dynamics of these pores.
Note the on-screen correction at 12:18. I meant to say 'greater' not 'smaller'.
The relevant paper is
https://www.cell.com/biophysj/fulltex...
Chapters:
0:00 Introduction
1:06 Theory
4:26 Hemifusion diaphragms
8:38 Rim pores on flat interfaces
12:54 Phenomenomogical model
15:33 Phenomenomogical model results
19:06 Testing critical pores
20:11 Preventing flipflops
20:49 Forming/growing a pore
22:21 Summary