Spore-Forming Bacteria in Multiple Sclerosis
To address the impact of microbiome on disease development, it is essential to go beyond a descriptive study and evaluate the physiological importance of microbiome changes. Our study integrates computational analysis with in vitro and in vivo exploration of inflammatory properties of spore-forming microbial communities, revealing novel functional correlations. We specifically show that while small differences exist between the microbiomes of MS patients and healthy subjects, these differences are exacerbated in the chloroform-resistant fraction. We further demonstrate that, when purified from MS patients, this fraction is correlated with impaired immunomodulatory responses in vitro.
DOI: https://doi.org/10.1128/mSystems.0008...
Title: Multiple Sclerosis-Associated Changes in the Composition and Immune Functions of Spore-Forming Bacteria
Authors: Egle Cekanaviciute, Anne-Katrin Pröbstel, Anna Thomann, Tessel F. Runia, Patrizia Casaccia, Ilana Katz Sand, Elizabeth Crabtree, Sneha Singh, John Morrissey, Patrick Barba, Refujia Gomez, Rob Knight, Sarkis Mazmanian, Jennifer Graves, Bruce A. C. Cree, Scott S. Zamvil, Sergio E. Baranzini (https://orcid.org/0000-0003-0067-194X)
Editor: Catherine Lozupone
Published in mSystems® on 6 November 2018
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