High-energy x-ray diffraction microscopy (HEDM) has provided new insights into grain-scale measurements of the 3D bulk microstructure and elastic strain, which can be coupled with environmental, thermal, or mechanical loading. The primary goals of this workshop are to bring researchers together to share their experiences using HEDM and discuss needs and ideas of the user community for the HEXM beamline after the APS-U. A combination of talks will include (i) discussions of the fundamentals of the techniques, beamlines, and reconstruction software to support HEDM, (ii) advancements of HEDM, including employing dynamic measurements or sub-grain measurements, such as diffraction tomography, Bragg coherent diffraction imaging, and dark field x-ray microscopy, and (iii) discussion of the applications of HEDM to solve fundamental science questions in materials science, including irradiation, thermo-mechanical loading, and electro-chemistry. During the workshop, we will discuss thoughts and ideas for new experiments in preparation for the HEXM beamline (20-ID) after the completion of the APS upgrade, including necessary software development efforts, the use of machine learning for data analysis, pseudo-real-time zoom-in experiments, etc.