LRHG Series - Lecture 22: Lessons to Remember from Lactase Deficiency - Lactase Persistance Projects
In this illuminating lecture, Professor Nabil Enattah—a pioneer in human genetics and Senior Researcher at the Libyan Biotechnology Research Center (BTRC), Tripoli—shares key insights from decades of research into lactase deficiency and lactase persistence. Drawing from both molecular genetics and population studies, Prof. Enattah examines how genetic adaptation shapes dietary tolerance across human populations and the implications for public health in North Africa and beyond.
This event is part of a continuing collaboration between CGC Tunis and the Institut Pasteur de Tunis.
00:02 – Introduction to the Lecture & Guest Speaker
04:09 – Congenital Lactose Deficiency: Disease Characteristics & Research Approach
08:07 – Identification of the Lactase Gene & Initial Findings
12:37 – The CD Project: Lessons Learned & Challenges Faced
17:23 – Discovery of a New Gene Associated with Congenital Lactose Deficiency
20:01 – Genetic Analysis of Lactose Persistence in Humans
24:19 – Selection Coefficient & Mechanisms Behind Lactose Persistence Evolution
28:34 – Study of Genetic Variants of Lactose Among Libyans
31:11 – Frequency of European Mutations in Libyan Population
33:48 – Association Between Abdominal Symptoms and Lactose Resistance
35:25 – Conclusion, Lessons Learned, & Final Thoughts
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