CCMB Seminar 02/07/2024 - Dr. Ravi Allada
на канале: University of Michigan Computational Medicine and Bioinformatics
CCMB Seminar
"Why Do We Sleep? The Circadian and Homeostatic Control of Sleep and wake"
Presented by
Ravi Allada, M.D.
Executive Director, Michigan Neuroscience Institute (MNI)
Theophile Raphael, M.D., Collegiate Professor of Neurosciences
Professor, Department of Anesthesiology
Introduced by Brian Athey, PhD
Michael Savageau Collegiate Professor & Chair
Department of Computational Medicine & Bioinformatics
Professor of Psychiatry
Abstract:
Why we sleep remains one of the most enduring mysteries in science. Sleep is homeostatically regulated where the duration of wakefulness drives subsequent sleep. Here we aim to determine how waking experience is sensed to trigger sleep and how sleep restores the brain? How does the circadian clock interact with the sleep homeostat? How does impaired sleep lead to human diseases such as Alzheimer’s disease. Our work makes widespread use of -omics approaches including for the identification of diagnostic biomarkers in human sleep disruption.
Short Bio:
Dr. Ravi Allada joined the Michigan Neuroscience Institute (MNI) on September 1, 2023, as the institute's new Executive Director. He comes to MNI from Northwestern University, where Dr. Allada served as Professor and Chair of the Department of Neurobiology, Professor in the Department of Pathology, and Associate Director of the Center for Sleep and Circadian Biology for 23 years. Dr. Allada received his M.D from the University of Michigan and completed a residency in Clinical Pathology at the Brigham and Women’s Hospital. During his training, he was an HHMI-NIH Research Scholar and an HHMI Physician Postdoctoral Fellow, the latter with 2017 Nobel Laureate Michael Rosbash. The Allada laboratory has discovered molecule “gears” of the core circadian clock including a link to neurodegenerative disease as well as pathways linking the core clock to daily rhythms of sleep and wake. His laboratory has also identified molecular processes underlying sleep including those linked to memory processing. His work extends discoveries in flies to mammals including the development of diagnostic biomarker signatures for circadian time and examining the effects of jet lag on athletic performance. His work has been funded by the NIH, DARPA as well as private foundations including a Burroughs Wellcome Career Award and a NARSAD Young Investigator Award. He has served as a member of the NIH Sleep Disorders Research Advisory Board and on the Board of Directors as for the Society for Research on Biological Rhythms and Sleep Research Society.