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The diagnosis for follicular lymphoma that has transformed into diffuse large B-cell lymphoma has in the past been associated with a poor prognosis for patients. However, in a National LymphoCare Study recently published in Blood, researchers assessed the incidence, prognostic features, and outcomes associated with the transformation of follicular lymphoma in enrolled patients. In this video Dr. John Leonard discusses the findings of the study. Specifically reviewed are new data on outcomes, based on novel approaches and therapies for patients whose follicular lymphoma has transformed.