Quick video showing off the level of 21:9 support to expect from Dishonored 2. Out of engine cutscenes are in 16:9, in engine cutscenes are rendered in 21:9. Gameplay is in native 21:9 with the field of view extended at the sides. The hud however stays in its original position from 16:9.
As an aside, performance on cards below 980ti/Fury X is reported to be worse than expected, with dips to around 40fps at times regardless of settings.