In addition to the formation of the Membrane Attack Complex to destroy microorganisms, the Complement System has other functions that are important for the inflammatory response and immunity in general.
#immunity #chemotaxis #opsonization
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Some articles consulted for this broadcast:
Nonaka, M., Yoshizaki, F. (2004). Evolution of the complement system. Molecular Immunology, 40, 897–902. doi:10.1016/j.molimm.2003.10.009
Lambris, J. D., Ricklin, D., Geisbrech, B. V. (2008). Complement evasion by human pathogens. Nature Reviews Microbiology, 6, 132-142. doi:10.1038/nrmicro1824
Zipfel, P.F. (2009). Complement and immune defense: from innate immunity to human diseases. Immunology Letters, 126, 1-7. doi:10.1016/j.imlet.2009.07.005
Ricklin, D., Hajishengallis, G., Lambris, J. D. (2010). Complement: a key system for immune surveillance and homeostasis. Nature Immunology, 11, 785-797. doi:10.1038/ni.1923
Bohlson, S. S., Garred, P., Kemper, C., Tenner, A. J. (2019). Complement Nomenclature - Deconvoluted. Frontiers in Immunology, 10, 1308. doi: 10.3389/fimmu.2019.01308
International Complement Society Newsletter, December 2020:
https://www.complement.org/
https://36de0f2b-fe99-4e13-aacb-8da2b...
Recommended Reading:
Male, D, Stokes Peebles, R, Male, V. (2021). Immunology. Elsevier.
Thao, D, Richard A. Harvey, RA. (2021). LIR Immunology. LWW Wolters Kluwer.
Abbas, AK, Lichtman, AH, Pillai, S. (2020). Basic Immunology. Elsevier.
Punt, J, Strandford, SA, Jones PP, Owen JA. (2020). Kubby. Immunology. McGraw Hill.
Sompayrac, LM. (2019). How the Immune System Works. Wiley-Blackwell
Tizard, I. (2019). Veterinary Immunology. Elsevier.