Six years after the events of Resident Evil 2, US agent Leon S. Kennedy is sent on a mission to rescue Ashley Graham, daughter of the US president, from a Spanish village controlled by the violent cult Los Iluminados. Other characters include Ada Wong, Leon's operator Ingrid Hunnigan, the civilian Luis Serra, and antagonists including Bitores Méndez, Ramón Salazar, Jack Krauser and Osmund Saddler.