Steroids and High Blood Pressure! Telmisartan Doesn't Work? Moon Face, Bloating and Water Retention.
Steroids and High Blood Pressure - How do steroids cause heart and kidney disease? Why doesn't Telmisartan always work? In this video we look at the way in which Testosterone (and Steroids, by proxy) cause high blood pressure through examining the effects of Testosterone on Mineralocorticoid pathways and receptors. We look specifically at Deoxy corticosteroid and how testosterone increases it. Is this the missing piece to the puzzle?
References:
(11beta-Hydroxysteroid dehydrogenase in the brain: a novel regulator of glucocorticoid action?, 1997)
(15638872)
([A comparative study of C19 steroid-induced hypertension and deoxycorticosterone acetate (DOCA)-salt hypertension]., 1984)
(Effects of dehydroepiandrosterone sulfate on the conversion of corticosterone into 11-dehydrocorticosterone in stress: a regulatory scheme., 2009)
(Hypertension due to a deoxycorticosterone-secreting adrenal tumour diagnosed during pregnancy., 2019)
(Effects of testosterone on the zona fasciculata of the male rat adrenal cortex. A correlated stereological and biochemical study., 1983)
(Novel effects of deoxycorticosterone on testicular 11beta-hydroxysteroid dehydrogenase activity and plasma testosterone levels in normal and adrenalectomized rats., 1999)
(Testosterone suppression of CRH-stimulated cortisol in men., 2005)
(Normal, bound and nonbound testosterone levels in normally ageing men: results from the Massachusetts Male Ageing Study., 2005)
(Spironolactone modulates expressions of cardiac mineralocorticoid receptor and 11beta-hydroxysteroid dehydrogenase 2 and prevents ventricular remodeling in post-infarct rat hearts., 2007)
(Role of the 11beta-hydroxysteroid dehydrogenase type 2 in blood pressure regulation., 2000)
(In vivo effects of stress, ACTH and corticosterone on testicular 11beta-hydroxysteroid dehydrogenase oxidative activity in rats and the possible mechanism of actions., 2000)
(Similarities and differences between effects of testosterone and 19-nortestosterone in rats, with particular reference to hypertensogenic potency., 1982)
Dr. Nicholas Downey:
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