What is Gain-of-Function research? Evolutionary question #23
Below are all the links you will need to do a deep dive into this terrifying topic... I hope you enjoy reading over 1000 pages of dooms-day horror mixed with legal and scientific jargon as I did!
My highlighted copy of the White-Paper: Gain-of-Function research ethical analysis:
https://drive.google.com/file/d/1PpyL...
NIH Definition of GoF research and resource links
https://osp.od.nih.gov/biotechnology/...
List of Select Agents. Research with these pathogens/toxins is strictly regulated by the US federal government.
https://www.selectagents.gov/sat/list...
2014 Pause on GoF research funding
https://www.phe.gov/s3/dualuse/Docume...
2014 GoF Government Workshop
https://www.nap.edu/download/21666
Risk and Benefit Analysis by Federal Government, 2016
http://gryphonsci.wpengine.com/wp-con...
Recommendations for Evaluation and Oversight of Proposed GoF Research, 2016
https://osp.od.nih.gov/wp-content/upl...
Review Requirements for GoF research, 2017
https://www.phe.gov/s3/dualuse/Docume...
Lift of GoF Funding Freeze by Federal Government
https://www.nih.gov/about-nih/who-we-...
List of Current GoF projects funded by US agencies
https://www.phe.gov/s3/dualuse/Pages/...
00:00 Introduction
00:47 Sources of information for this presentation
02:17 Audience questions about Gain of Function research
03:33 First controversial virology experiment
05:27 Factory Farming and virus evolution
08:06 Origin of the 1918 Spanish Flu
09:30 Publication of the first dangerous Gain of Function experiment H5N1
12:25 Dr. Fauci supports the work but gives word of caution on Gain of Function experiments
13:24 Dr. David Relman warns that certain types of Gain of Function research is unethical
14:18 Controversial Gain of Function research continues in US labs, early 2014
16:02 Three US Lab accidents trigger halt on GoF Research, late 2014
18:46 Gain of Function defined, as it applies to the research ban
19:46 Purpose of Gain of Function research
22:47 How does Gain of Function research work?
28:08 Risks of Gain of Function research
32:10 Safer Alternatives
34:10 Gain of Function research started again in 2017 with new guidelines
35:15 Jon Perry's thoughts on all of this