Nullranges: Modular Workflow For Overlap Enrichment
Wancen Mu and Eric Scott Davis, Biostatistics Ph.D. students at the University of North Carolina at Chapel Hill, gave a workshop at the BioConductor Conference 2022. The workshop presented by the team was on Nullranges: Modular Workflow For Overlap Enrichment.
From the Bioconductor Conference 2022
Author(s): Wancen Mu, Eric Scott Davis, Mikhail Dozmorov, Stuart Lee, Michael I Love, Douglas Phanstiel
Affiliation(s): University of North Carolina at Chapel Hill
There are many well-established packages for overlap enrichment in R/Bioconductor. These can be used to establish if two sets of genomic ranges are distributed closer to each other than expected under a particular null hypothesis. In this software demo we will focus on two branches of specification of null hypothesis for distribution of genomic ranges, where we find it is beneficial to separate generation of null ranges from the enrichment analysis steps. These are cases where the specification of the null hypothesis is complex in itself and deserves its own multiple steps, diagnostic considerations, and plots all covered in our workshop. Finally, we will demonstrate how nullranges plays a role in a tidy data workflow tying together multiple Bioconductor and tidyverse packages.
Package demo details
https://ericscottdavis.com/Bioc2022nu...
Source code
https://github.com/EricSDavis/Bioc202...
More Resources
Bioconductor Conference Site: https://bioc2022.bioconductor.org/
BioC2022 Github: https://github.com/Bioconductor/BioC2022
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