Irreducible Complexity describes a system that requires all of its parts for it to function, i.e., a mousetrap. Cells need to make molecular machines, i.e., ATP synthase rotors. To make each protein to produce a rotor often requires hundreds of steps, but to produce those proteins, the functioning rotor is required.
The 'spaghettification' of irreducible complexity is a true Achille's heel for evolution.
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