R is for randomization: complex randomization of patients in clinical trials
From R/Medicine Conference 2022
Steven Schwager is a Professor Emeritus at Cornell University and Chair of the Executive Advisory Board at White Paper Capital Partners
Sections
0:00 Introduction
1:11 The need for efficient randomization
2:32 Advantages of randomization
3:15 Overview: basic types of randomization
5:36 Evaluating randomization plan performance
7:10 Complete randomization
8:09 Stratified permuted block randomization
9:19 DA/ Covariate adjusted randomization
12:35 DA/ Covariate adjusted randomization details 1 and 2
15:26 Statistical analysis for randomization methods
16:38 Dynamic allocation example of DA1, Best, and 2nd best
17:08 Dynamic allocation example of DA2, complete Randzn
17:52 DA / Covariate adjusted randomization in R
19:00 Comparing randomization methods
19:26 Conclusions on comparing randomization models
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