Biological and morphological subtypes of breast cancer
📆 Live broadcast with Dr. Bessonov.
Topic: "Biological and morphological subtypes of breast cancer."
TNBC chat https://t.me/+TjCEJlv8CZlhZGI6
👨⚕️ Alexander Alekseevich Bessonov – mammologist-oncologist, PhD, Head of the Breast Tumor Department at the Leningrad Regional Clinical Hospital, Associate Professor at the Petrov National Medical Research Center of Oncology, Director of the Remission Clinic.
🔸 Graduated with honors from the St. Petersburg State Pediatric Medical University: residency in oncology, internship in surgery;
🔸 Member of the European Society of Surgical Oncologists (ESSO), the European Society of Medical Oncologists (ESMO), and the Russian Society of Oncologists-Mammologists (ROSM);
🔸 runs his own Telegram channel https://t.me/doc_bessonov.
📺The broadcast took place on the channel
https://t.me/triplyatavmeste
Biological and morphological subtypes of breast cancer
00:00:00 Introduction
• Waiting for the doctor to join.
• Introduction of Alexander Alekseevich.
00:03:42 Introduction of Alexander Alekseevich
• Alexander Bessonov is the head of the breast tumor department at the Leningrad Regional Clinical Hospital.
• PhD in Medicine, dissertation on hereditary forms of breast cancer.
• Experience at the Nikolai Nikolaevich Petrov Oncology Institute and other oncology centers.
• Specialist in reconstructive plastic surgery.
• Director of the Remission Clinic, specializing in postoperative rehabilitation.
00:05:54 Topic of the Broadcast
• Discussion of morphological and biological types of triple-negative breast cancer.
• Mention of the channel community and patient consultations.
• Recommendation of Nikita Savelov's lecture for a deeper understanding of the topic.
00:07:49 History of Breast Cancer Research
• Breast cancer was previously considered a monomorphic disease, but its diversity was later discovered.
• Histological types of cancer: tubular, papillary, mucinous, adenoid cystic, and others.
• More than 80% of cases are classified as unspecified breast cancer.
00:09:38 Histological Diversity
• The histological diversity of breast cancer has long been evident.
• Morphologists and oncologists have studied the relationship between the histological picture and the clinical course of the disease. • Attempts to formulate treatment concepts based on histological data.
00:10:12 Diagnosis of Lobular Breast Cancer
00:11:09 Treatment of Lobular Cancer
00:12:08 Classification of Breast Cancer
00:13:03 Triple-Negative Breast Cancer
00:15:03 Molecular Subtypes of Triple-Negative Cancer
00:16:44 Indolent Subtypes of Triple-Negative Cancer
00:17:43 Off-Label Therapy
00:20:17 Use of Capecitabine
• Studies show the effectiveness of capecitabine in the postoperative period for triple-negative breast cancer.
• Japanese and Chinese studies have confirmed improved treatment outcomes with capecitabine. 00:22:25 Spanish Capecitabine Study
• Basal-like carcinoma is triple-negative in 95% of cases.
00:24:33 Definition of basal-like carcinoma
• Basal-like carcinoma has a gene expression profile similar to that of ductal basal cells.
00:25:42 BRCA Mutation and Genetic Testing
00:27:27 Interaction of Platinum and Laparib
00:30:23 Complete Pathomorphosis and Immune Response
00:33:08 Administration of Parap-Inhibitors
00:34:19 Factors Affecting Cancer Treatment
00:35:49 Immunohistochemical Diagnostics
00:36:43 Androgen Receptors and Prognosis
00:37:40 Metaplastic Carcinoma
00:40:26 Angiogenic Therapy and Biocizumab
00:41:22 Evaluation of Treatment Efficacy
00:43:17 Surgical Intervention
00:45:47 Approach at the Gustav Russ Institute
00:46:26 Radical Treatment of Breast Cancer
00:47:16 Metaplastic Carcinoma and non-universal therapy
• Metaplastic carcinoma responds poorly to non-universal therapy; there is no standard treatment approach.
00:48:33 Medullary breast cancer
00:51:03 Apocrine differentiation of triple-negative breast cancer
• Apocrine triple-negative breast cancer is a rare subtype, and there is little research on its treatment.
00:53:52 Targeted Therapy and Biodiversity
00:55:47 Antiandrogen Therapy
00:56:48 Post-Treatment Patient Examination Issues
00:58:30 Focus on Local Control
01:00:20 Psychological Aspects of Examinations
01:02:02 Examination Recommendations
01:04:57 Post-Treatment Examinations
01:06:24 Brain MRI
01:08:18 Symptomatic Examination
01:09:31 Opinions on Reconstructive Surgeries
01:10:27 Reconstruction Issues
01:11:20 Implant Covering Techniques
01:12:07 Treatment of Rare Cancer Subtypes
01:16:35 Signature Analysis
01:19:08 Application of Signature Analysis in Clinical Practice Practice
01:20:23 Therapeutic intervention when circulating tumor DNA is detected
01:21:22 Risks and recommendations
01:22:15 Conclusion
• Thank you for an interesting conversation and deepening our knowledge of the morphological types of breast cancer.
• Emphasizing the importance of patient communities for education.
01:23:09 Clinical aspects
01:23:56 Farewell
Questions from girls